D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons.

@article{Martina2003DSerineDM,
  title={D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons.},
  author={Marzia Martina and Nicholas V Krasteniakov and Richard Bergeron},
  journal={The Journal of physiology},
  year={2003},
  volume={548 Pt 2},
  pages={411-23}
}
The organization of the neuronal hippocampal network depends on the tightly regulated interaction between pyramidal cells (PCs) and interneurons (Ints). NMDA receptor (NMDAR) activation requires the binding of glutamate and co-activation of the 'glycine site'. It has been reported that D-serine is a more potent endogenous agonist than glycine for that site. While many studies have focused on NMDAR function in PCs, little is known regarding the modulation of NMDARs in Ints. We studied the… CONTINUE READING

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