D-Serine dehydratase from chicken kidney: a vertebral homologue of the cryptic enzyme from Burkholderia cepacia.

@article{Tanaka2008DSerineDF,
  title={D-Serine dehydratase from chicken kidney: a vertebral homologue of the cryptic enzyme from Burkholderia cepacia.},
  author={Hiroyuki Tanaka and Atsushi Yamamoto and Tetsuo Ishida and Kihachiro Horiike},
  journal={Journal of biochemistry},
  year={2008},
  volume={143 1},
  pages={49-57}
}
D-serine dehydratase (DSD) catalyses the conversion of d-serine to pyruvate and ammonia. d-Serine is a physiological modulator of glutamate neurotransmission in vertebrate brains. In mammals d-serine is degraded by d-amino-acid oxidase, whereas in chicken brain it is degraded by DSD, as we have recently demonstrated [Tanaka et al. (2007) Anal. Biochem. 362, 83-88]. To clarify the roles of DSD in avian species, we purified DSD from chicken kidney. The purified enzyme was a heterodimer consisting… CONTINUE READING

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