D-Serine Regulation of NMDA Receptor Activity

  title={D-Serine Regulation of NMDA Receptor Activity},
  author={Herman Wolosker},
  journal={Science's STKE},
  pages={pe41 - pe41}
The N-Methyl-D-aspartate–type glutamate receptor (NMDAR) plays a key role in several important processes involving the nervous system, including brain development, synaptic plasticity, and learning. Unlike other neurotransmitter receptors, which are activated by individual neurotransmitters, activation of NMDARs requires the binding of a coagonist (D-serine or glycine) in addition to glutamate. Although previously considered an "unnatural" amino acid, D-serine is a key regulator of NMDAR… 

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