D-Serine Regulation of NMDA Receptor Activity

@article{Wolosker2006DSerineRO,
  title={D-Serine Regulation of NMDA Receptor Activity},
  author={Herman Wolosker},
  journal={Science's STKE},
  year={2006},
  volume={2006},
  pages={pe41 - pe41}
}
The N-Methyl-D-aspartate–type glutamate receptor (NMDAR) plays a key role in several important processes involving the nervous system, including brain development, synaptic plasticity, and learning. Unlike other neurotransmitter receptors, which are activated by individual neurotransmitters, activation of NMDARs requires the binding of a coagonist (D-serine or glycine) in addition to glutamate. Although previously considered an "unnatural" amino acid, D-serine is a key regulator of NMDAR… 
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68 Citations
Background Citations
36
Methods Citations
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Results Citations
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68 Citations

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Reduced D-Serine Release May Contribute to Impairment of Long-Term Potentiation by Corticosterone in the Perforant Path-Dentate Gyrus

Hypofunction of NMDA receptors may be involved in impairment of LTP by corticosterone and reduced D-serine release may be an important reason for its hypofunction, which is an important complement to existing mechanisms of cortic testosterone-induced LTP and cognitive impairment.

Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice

A role for D-serine in neurodevelopment is indicated and novel insights on how to interpret data of psychiatric genetics are provided, indicating the involvement of genes associated with D-Serine synthesis and degradation, as well as how to consider animal models with neonatal application of NMDA receptor antagonists.

An Insight into Animal Glutamate Receptors Homolog of Arabidopsis thaliana and Their Potential Applications—A Review

A high throughput approach based on FRET nanosensors developed for understanding neurotransmitter signaling in animals and plants via glutamate receptors has been discussed and will aid in the future comprehension of the complex molecular dynamics of glutamate receptors and the exploration of new facts in plant/animal biology.

Properties of NMDA receptors in the rat basal ganglia.

The NMDA-induced whole-cell currents display a high ifenprodil sensitivity, suggesting the presence of NR2B-containingNMDA receptors on P7 rat SNc neurons, and direct transition analysis suggests that the small conductance channels may be due to NR2D-containing NMDA receptors.
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References

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