D-Lysergyl peptide synthetase from the ergot fungus Claviceps purpurea.

  title={D-Lysergyl peptide synthetase from the ergot fungus Claviceps purpurea.},
  author={Beat Riederer and M Han and Ullrich Keller},
  journal={The Journal of biological chemistry},
  volume={271 44},
The ergot fungus Claviceps purpurea produces the medically important ergopeptines, which consist of a cyclol-structured tripeptide and D-lysergic acid linked by an amide bond. An enzyme activity capable of non-ribosomal synthesis of D-lysergyl-L-alanyl-L-phenylalanyl-L-proline lactam, the non-cyclol precursor of the ergopeptine ergotamine, has been purified about 18-fold from the ergotamine-producing C. purpurea strain D1. Analysis of radioactively labeled enzyme-substrate complexes revealed a… CONTINUE READING


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