D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma.

@article{Eshraghi2006DJNKI1TP,
  title={D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma.},
  author={Adrien A. Eshraghi and Jiao He and Cai Hong Mou and Marek Polak and Azel Zine and Christophe Bonny and Thomas J. Balkany and Thomas R Van De Water},
  journal={Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  year={2006},
  volume={27 4},
  pages={
          504-11
        }
}
HYPOTHESES 1) Hearing loss caused by electrode insertion trauma has both acute and delayed components; and 2) the delayed component of trauma-initiated hearing loss can be prevented by a direct delivery of a peptide inhibitor of the c-Jun N-terminal kinase cell death signal cascade, that is, D-JNKI-1, immediately after the electrode insertion within the cochlea. BACKGROUND Acute trauma to the macroscopic elements of the cochlea from electrode insertion is well known. The impact of trauma… CONTINUE READING
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