D-Amino acid metabolism in mammals: biosynthesis, degradation and analytical aspects of the metabolic study.

@article{Ohide2011DAminoAM,
  title={D-Amino acid metabolism in mammals: biosynthesis, degradation and analytical aspects of the metabolic study.},
  author={Hiroko Ohide and Yurika Miyoshi and Rindo Maruyama and Kenji Hamase and Ryuichi Konno},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2011},
  volume={879 29},
  pages={3162-8}
}
It was believed for long time that d-amino acids are not present in mammals. However, current technological advances and improvements in analytical instruments have enabled studies that now indicate that significant amounts of D-amino acids are present in mammals. The most abundant D-amino acids are D-serine and D-aspartate. D-Serine, which is synthesized by serine racemase and is degraded by D-amino-acid oxidase, is present in the brain and modulates neurotransmission. D-Aspartate, which is… CONTINUE READING
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