D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.

  title={D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.},
  author={Dalei Wu and Yunhua Kong and Cong Han and Jing Chen and Lihong Hu and Hualiang Jiang and Xu Shen},
  journal={International journal of antimicrobial agents},
  volume={32 5},
Flavonoids are polyphenolic compounds that are ubiquitous in nature. They possess varied promising properties for medical use. Quercetin (3,3',4',5,7-pentahydroxyflavone) and apigenin (4',5,7-trihydroxyflavone) are two representative flavonoids, both of which have been reported to possess antibacterial activity by acting on multiple targets. Here, we determined that d-alanine:d-alanine ligase (Ddl) is another new target for quercetin and apigenin. Kinetic analysis indicated that these two… CONTINUE READING
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