D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.

@article{Wu2008DAlanineDalanineLA,
  title={D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.},
  author={Dalei Wu and Yunhua Kong and Cong Han and J. Chen and L. Hu and H. Jiang and Xu Shen},
  journal={International journal of antimicrobial agents},
  year={2008},
  volume={32 5},
  pages={
          421-6
        }
}
Flavonoids are polyphenolic compounds that are ubiquitous in nature. They possess varied promising properties for medical use. Quercetin (3,3',4',5,7-pentahydroxyflavone) and apigenin (4',5,7-trihydroxyflavone) are two representative flavonoids, both of which have been reported to possess antibacterial activity by acting on multiple targets. Here, we determined that d-alanine:d-alanine ligase (Ddl) is another new target for quercetin and apigenin. Kinetic analysis indicated that these two… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds.
Allosteric inhibition of Staphylococcus aureus d-alanine:d-alanine ligase revealed by crystallographic studies
Antimicrobial activity of flavonoids
Phosphinic acid inhibitors of D-alanyl-D-alanine ligase.
The biochemistry and medical significance of the flavonoids.
  • B. Havsteen
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 2002
Characterization of quercetin binding site on DNA gyrase.
...
1
2
3
...