D-4F Decreases White Matter Damage After Stroke in Mice.

  title={D-4F Decreases White Matter Damage After Stroke in Mice.},
  author={Xu Cui and Michael Chopp and Alex Zacharek and Chengcheng Cui and Tao Yan and Ruizhuo Ning and Jieli Chen},
  volume={47 1},
BACKGROUND AND PURPOSE Stroke-induced neuroinflammation and white matter damage are associated with neurological deficits. Whether D-4F, an apolipoprotein A-I mimetic peptide, treatment of stroke decreases neuroinflammation and white matter damage and improves functional outcome has not been investigated. METHODS Adult male C57BL/6 mice were subjected to permanent middle cerebral artery occlusion (MCAo) and were orally administered saline as a vehicle control and different doses of D-4F (2, 4… CONTINUE READING
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