D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD.

@article{Ganapathy2012D4FAA,
  title={D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD.},
  author={Ekambaram Ganapathy and Feng Su and David Meriwether and Asokan Devarajan and Victor R. Grijalva and Feng Gao and Arnab Chattopadhyay and G. M. Anantharamaiah and Mohamad Navab and Alan M. Fogelman and Srinivasa T. Reddy and Robin Farias-Eisner},
  journal={International journal of cancer},
  year={2012},
  volume={130 5},
  pages={1071-81}
}
We recently reported that apoA-I and apoA-I mimetic peptides prevent the development of flank tumors in immunocompetent C57BL/6J mice. To delineate the mechanism(s) of action of apoA-I mimetic peptides in tumor development, we examined the effect of D-4F (an apoA-I mimetic peptide) on the antioxidant status and on the gene expression and function of antioxidant enzymes in ID8 cells (a mouse epithelial ovarian cancer cell line) and in a mouse model. We demonstrate that D-4F treatment… CONTINUE READING