D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures.

@article{Tober1996D23129AP,
  title={D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures.},
  author={Christine Tober and A. Rostock and Chris Rundfeldt and R{\"u}diger Bartsch},
  journal={European journal of pharmacology},
  year={1996},
  volume={303 3},
  pages={163-9}
}
The novel anticonvulsant drug D-23129 (N-(2-amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester) was evaluated in the amygdala kindling model of complex partial seizures in rats. D-23129 exerts potent anticonvulsant activity against both focal and generalized seizures in animal models of epilepsy. After intraperitoneal and oral administration in kindled rats, the substance dose dependently increased the threshold for induction of afterdischarges, exerting significant effects already… CONTINUE READING