D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth

  title={D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth},
  author={Shenghong Ma and Bowen Jiang and Wanglong Deng and Zhongkai Gu and Fei-Zhen Wu and T. Li and Yukun Xia and Hui Yang and D. Ye and Y. Xiong and K. Guan},
  pages={8606 - 8620}
  • Shenghong Ma, Bowen Jiang, +8 authors K. Guan
  • Published 2015
  • Medicine, Biology
  • Oncotarget
  • Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α-KG to produce D-2-hydroxyglutarate (D-2-HG), which is proposed to function as an oncometabolite by inhibiting α-KG dependent dioxygenases. We investigated the function of D-2-HG in tumorigenesis using IDH1 and IDH2 mutant cancer cell lines. Inhibition of D-2-HG production either by specific deletion of the mutant IDH1-R132C allele or overexpression of D-2-hydroxyglutarate dehydrogenase (D2HGDH… CONTINUE READING
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