D‐chiro‐Inositol found in Cucurbita ficifolia (Cucurbitaceae) fruit extracts plays the hypoglycaemic role in streptozocin‐diabetic rats

  title={D‐chiro‐Inositol found in Cucurbita ficifolia (Cucurbitaceae) fruit extracts plays the hypoglycaemic role in streptozocin‐diabetic rats},
  author={Tao Xia and Qin Wang},
  journal={Journal of Pharmacy and Pharmacology},
  • Tao Xia, Qin Wang
  • Published 1 November 2006
  • Biology, Medicine
  • Journal of Pharmacy and Pharmacology
Cucurbita ficifolia is commonly used as an antihyperglycaemic agent in Asia. However, the mechanism of its action is unknown. Chemically synthesized D‐chiro‐inositol (D‐CI), a component of an insulin mediator, has been demonstrated to have antihyperglycaemic effects in rats. In this study, we found that C. ficifolia contained fairly high levels of D‐CI, thus, C. ficifolia may be a natural source of D‐CI for reducing blood glucose concentrations in diabetics. We evaluated C. ficifolia fruit… 


The hypoglycemic effect of this extract may be partially explained by liver glycogen accumulation in diabetic mice, and the histological architecture evidenced a liver-protective effect due the extract.

Cucurbita ficifolia Bouché fruit acts as an insulin secretagogue in RINm5F cells

The aim of the present investigation was to determine if the hypoglycemic action of C. ficifolia and D-chiro-Inositol occurs through an increase in the production of insulin, which suggests a mechanism of action that involves both the expression and secretion of insulin.

Antioxidant and anti-inflammatory effects of a hypoglycemic fraction from Cucurbita ficifolia Bouché in streptozotocin-induced diabetes mice.

Results suggest that C. ficifolia might be used as an alternative medication for the control of diabetes mellitus and that it has antioxidant and anti-inflammatory properties in addition to its hypoglycemic activity.

Hypoglycemic effect and bioactive compounds associated with the ripening stages of the Cucurbita ficifolia Bouché fruit.

BACKGROUND The fruit of Cucurbita ficifolia Bouche is known in Mexico as 'chilacayote'. The scientific interest that C. ficifolia Bouche has acquired is due to its important hypoglycemic effect. The

Hypoglycemic effect and bioactive compounds associated with the maturity stages of Cucurbita ficifolia Bouché fruit.

All stages of development of C. ficifolia fruit had a hypoglycemic effect, however, the aqueous extract from the fruit of 15 days of development showed a remarkable and better effect than glibenclamide, highlighting the potential of this maturity stage as the most appropriate to be included in treatments of type 2 diabetes mellitus.

4-Hydroxybenzoic Acid and β-Sitosterol from Cucurbita ficifolia Act as Insulin Secretagogues, Peroxisome Proliferator-Activated Receptor-Gamma Agonists, and Liver Glycogen Storage Promoters: In Vivo, In Vitro, and In Silico Studies.

In silico study revealed that 4-HBA and β-sitosterol have potential as dual agonists on PPARγ and GPR40 receptors, and both compounds should be considered in the development of new antidiabetic drug development.

In Vitro Role of Pumpkin Parts as Pharma-Foods: Antihyperglycemic and Antihyperlipidemic Activities of Pumpkin Peel, Flesh, and Seed Powders, in Alloxan-Induced Diabetic Rats

It is concluded that pumpkin has high potential to be used in human diet to cope with noncommunicable diseases like diabetes and hypercholesterolemia.



Anti-hyperglycemic effect of some edible plants.

Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys.

D-CI administration, therefore, lowered elevated plasma glucose in streptozotocin-treated hyperglycemic rats, normal rats given a glucose load, and spontaneously insulin-resistant monkeys with or without noninsulin-dependent diabetes mellitus.

Antidiabetic effect of Cogent db, a herbal drug in alloxan-induced diabetes mellitus.

  • L. PariG. Saravanan
  • Biology, Chemistry
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
  • 2002

D-Chiro-Inositol – Its Functional Role in Insulin Action and its Deficit in Insulin Resistance

  • J. Larner
  • Biology
    International journal of experimental diabetes research
  • 2002
In this review we discuss the biological significance of D-chiro-inositol, originally discovered as a component of a putative mediator of intracellular insulin action, where as a putative mediator,

Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with manganese in streptozotocin diabetic rats.

Three components of the pH 2.0 putative mediator of insulin action and D-Chiro-inositol and manganese are examined in low dose streptozotocin-treated rats, having an important role in glucose uptake, insulin release and mediator generation.

Fagopyritol B1, O-α-D-galactopyranosyl-(1→2)-D-chiro-inositol, a galactosyl cyclitol in maturing buckwheat seeds associated with desiccation tolerance

It is proposed that fagopyritol B1 facilitates desiccation tolerance and storability of buckwheat seeds.

D-chiro-inositol metabolism in diabetes mellitus.

The metabolism of D-chiro-inositol is abnormal in diabetes and appears to be influenced by short- and long-term metabolic control.