D‐Amino acid residue in the C‐type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus

@article{Torres2002DAminoAR,
  title={D‐Amino acid residue in the C‐type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus},
  author={A. Torres and I. Menz and P. Alewood and P. Bansal and J. Lahnstein and C. Gallagher and P. Kuchel},
  journal={FEBS Letters},
  year={2002},
  volume={524}
}
  • A. Torres, I. Menz, +4 authors P. Kuchel
  • Published 2002
  • Biology, Medicine
  • FEBS Letters
  • The C‐type natriuretic peptide from the platypus venom (OvCNP) exists in two forms, OvCNPa and OvCNPb, whose amino acid sequences are identical. Through the use of nuclear magnetic resonance, mass spectrometry, and peptidase digestion studies, we discovered that OvCNPb incorporates a D‐amino acid at position 2 in the primary structure. Peptides containing a D‐amino acid have been found in lower forms of organism, but this report is the first for a D‐amino acid in a biologically active peptide… CONTINUE READING
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