D‐ AND L‐STEREOISOMERS OF ALLYLGLYCINE: CONVULSIVE ACTION AND INHIBITION OF BRAIN L‐GLUTAMATE DECARBOXYLASE

@article{Orlowski1977DAL,
  title={D‐ AND L‐STEREOISOMERS OF ALLYLGLYCINE: CONVULSIVE ACTION AND INHIBITION OF BRAIN L‐GLUTAMATE DECARBOXYLASE},
  author={M. Orlowski and D. F. Reingold and M. Stanley},
  journal={Journal of Neurochemistry},
  year={1977},
  volume={28}
}
  • M. Orlowski, D. F. Reingold, M. Stanley
  • Published 1977
  • Chemistry, Medicine
  • Journal of Neurochemistry
  • DL‐Allylglycine was resolved into the L‐ and D‐stereoisomers using hog kidney acylase. Both isomers were active as convulsants after administration to mice. The dose of D‐allylglycine required to induce convulsions was greater than that of the L‐isomer. Studies on the concentration of the two isomers in brain suggest that the lower effectiveness of D‐allylglycine is partially due to its slower penetration into the brain through the blood‐brain barrier. 
    61 Citations
    Allylglycine: intranigral effects and reappraisal of actions on the GABA system.
    • 8
    The effects of allylglycine on GABA synthesis in vivo.
    • 5
    The role of 2-keto-4-pentenoic acid in seizures induced by allylglycine.
    • R. Horton
    • Chemistry, Medicine
    • Biochemical pharmacology
    • 1978
    • 18

    References

    SHOWING 1-10 OF 17 REFERENCES
    Identification of L-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine.
    • W. B. Rowe, A. Meister
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1970
    • 73
    • PDF
    Some properties of L-glutamic decarboxylase in mouse brain.
    • 325