• DOI:10.1111/j.1471-4159.1977.tb07754.x
Corpus ID: 34674552

D‐ AND L‐STEREOISOMERS OF ALLYLGLYCINE: CONVULSIVE ACTION AND INHIBITION OF BRAIN L‐GLUTAMATE DECARBOXYLASE

@article{Orlowski1977DAL,
  title={D‐ AND L‐STEREOISOMERS OF ALLYLGLYCINE: CONVULSIVE ACTION AND INHIBITION OF BRAIN L‐GLUTAMATE DECARBOXYLASE},
  author={M. Orlowski and D. F. Reingold and M. Stanley},
  journal={Journal of Neurochemistry},
  year={1977},
  volume={28}
}

M. Orlowski, D. F. Reingold, M. Stanley

Published 1977

Chemistry, Medicine

Journal of Neurochemistry

View on Wiley

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed

DL‐Allylglycine was resolved into the L‐ and D‐stereoisomers using hog kidney acylase. Both isomers were active as convulsants after administration to mice. The dose of D‐allylglycine required to induce convulsions was greater than that of the L‐isomer. Studies on the concentration of the two isomers in brain suggest that the lower effectiveness of D‐allylglycine is partially due to its slower penetration into the brain through the blood‐brain barrier.