D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neurons.

@article{Wang2001D1DR,
  title={D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neurons.},
  author={Junli Wang and Patricio O'donnell},
  journal={Cerebral cortex},
  year={2001},
  volume={11 5},
  pages={
          452-62
        }
}
The interactions between N-methyl-D-aspartate (NMDA) and D(1) dopamine receptors in the rat prefrontal cortex were examined using whole-cell recordings from pyramidal neurons. The effects of NMDA, the D(1) agonist SKF38393, or both compounds combined were tested on measures of cell excitability. Both NMDA (10-100 microM) and SKF38393 (5-10 microM) independently increased the number of spikes and decreased the latency of the first spike evoked by intracellular depolarizing current pulses… CONTINUE READING

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