D(1) dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures.

@article{Chao2002D1DR,
  title={D(1) dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures.},
  author={Steven Z Chao and Wenxiao Lu and Hey-Kyoung Lee and Richard L. Huganir and Marina E Wolf},
  journal={Journal of neurochemistry},
  year={2002},
  volume={81 5},
  pages={984-92}
}
Postsynaptic interactions between dopamine and glutamate receptors in the nucleus accumbens are critical for acute responses to drugs of abuse and for neuroadaptations resulting from their chronic administration. We tested the hypothesis that D(1) dopamine receptor stimulation increases phosphorylation of the AMPA receptor subunit GluR1 at the protein kinase A phosphorylation site (Ser845). Nucleus accumbens cell cultures were prepared from postnatal day 1 rats. After 14 days in culture, GluR1… CONTINUE READING

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