CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.

@article{Perron2004CzcRCzcSAT,
  title={CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.},
  author={Karl Perron and Olivier Caille and Claude Rossier and Christian van Delden and John H. Dumas and Thilo K{\"o}hler},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 10},
  pages={8761-8}
}
Pseudomonas aeruginosa is an environmental bacterium involved in mineralization of organic matter. It is also an opportunistic pathogen able to cause serious infections in immunocompromised hosts. As such, it is exposed to xenobiotics including solvents, heavy metals, and antimicrobials. We studied the response of P. aeruginosa upon exposure to heavy metals or antibiotics to investigate whether common regulatory mechanisms govern resistance to both types of compounds. We showed that sublethal… CONTINUE READING

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