Cytovaricin B, a new inhibitor of JAK-STAT signal transduction produced by Streptomyces torulosus.

  title={Cytovaricin B, a new inhibitor of JAK-STAT signal transduction produced by Streptomyces torulosus.},
  author={Noriyuki Yamashita and Shin‐ya Kazuo and Makoto Kitamura and Hiroshi Wakao and Kazuo Furihata and Yoichi Hayakawa and Atsushi Miyajima and Haruo Seto},
  journal={The Journal of antibiotics},
  volume={50 5},
effect on normal haematopoiesis9). In order to study the role of STAT5in IL-3 signaling, and to find new growth inhibitors of leukaemic cells, we have screened inhibitors of STAT5from microbial metabolites using a luciferase reporter system in IL-3 dependent Ba/F3 cells. The cells were transfected with reporter plasmid consisting of luciferase gene under the control of the jS-casein promoter having STAT5 binding sites. In this system, the expression of the luciferase MAY 1997 

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