Cytotoxicity on tumor cells of peripheral blood monocytes and tumor-associated macrophages in patients with ascites ovarian tumors.

@article{Mantovani1980CytotoxicityOT,
  title={Cytotoxicity on tumor cells of peripheral blood monocytes and tumor-associated macrophages in patients with ascites ovarian tumors.},
  author={Alberto Mantovani and Nadia Polentarutti and Giuseppe Peri and Z B Shavit and Annunciata Vecchi and Giorgio Bolis and Costantino Mangioni},
  journal={Journal of the National Cancer Institute},
  year={1980},
  volume={64 6},
  pages={1307-15}
}
Mononuclear phagocytes were isolated from the peripheral blood (PB) and ascites tumors of 35 patients with epithelial ovarian tumors. After 48 hours of incubation with the TU5 tumor, tumor-associated macrophages (TAM) and PB monocytes from cancer patients showed lower cytolytic activity than did control cells, but by 72 hours there was little difference between control and ovarian cancer effector cells. Primary ovarian carcinoma cultures were heterogeneous in their susceptibility to macrophage… CONTINUE READING

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