Cytotoxicity of zinc in vitro.

@article{Borovansk1989CytotoxicityOZ,
  title={Cytotoxicity of zinc in vitro.},
  author={J Borovansk{\'y} and Patrick A Riley},
  journal={Chemico-biological interactions},
  year={1989},
  volume={69 2-3},
  pages={279-91}
}
The effect of zinc ions on B16 mouse melanoma lines, HeLa cells and I-221 epithelial cells was investigated in vitro in order to ascertain whether sensitivity to Zn2+ is a general feature of cells in vitro and in an attempt to elucidate the mechanism(s) of zinc cytotoxicity. The proliferation of B16, HeLa and I-221 cell lines was inhibited by 1.25 x 10(-4), 1.50 x 10(-4) and 1.50 x 10(-4) mol/l Zn2+, respectively. The free radical scavengers, methimazole and ethanol, did not suppress the… CONTINUE READING

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