Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts.

@article{Yui1994CytotoxicityOT,
  title={Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts.},
  author={Jyoji Yui and M I Garc{\'i}a-Lloret and Thomas Wegmann and Larry J. Guilbert},
  journal={Placenta},
  year={1994},
  volume={15 8},
  pages={819-35}
}
Tumour necrosis factor-alpha (TNF-alpha) and gamma interferon (IFN-gamma) are expressed within human placental villi during normal pregnancy, yet their functions remain unknown. Since villous cytotrophoblasts are within the paracrine reach of this expression, the effects of TNF-alpha and IFN-gamma on a purified population of term placental cytotrophoblasts were examined. After 4 days of culture TNF-alpha alone induced a loss of trophoblast viability as measured by both metabolic capacity (MTT… CONTINUE READING

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