Cytotoxicity of nanoparticles independent from oxidative stress.

  title={Cytotoxicity of nanoparticles independent from oxidative stress.},
  author={Eleonore Fr{\"o}hlich and Claudia Samberger and Tatjana Kueznik and Markus Absenger and Eva Roblegg and Andreas Zimmer and Thomas R. Pieber},
  journal={The Journal of toxicological sciences},
  volume={34 4},
The use of nano-sized materials offers exciting new options in technical and medical applications. On the other hand, adverse effects on cells have been reported and may limit their use. In addition to physico-chemical parameters such as contamination with toxic elements, fibrous structure and high surface charge, the generation of radical species was identified as key mechanism for cytotoxic action of nanoparticles. The cytotoxic potential of nanoparticles in the absence of radical generation… CONTINUE READING