Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells.

@article{Pote2000CytotoxicityOM,
  title={Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells.},
  author={A Pote and Craig W Zwizinski and Eric E. Simon and Suzanne Meleg-Smith and Vecihi Batuman},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2000},
  volume={36 4},
  pages={735-44}
}
We evaluated the effect of eight species of light chains on cultured human kidney proximal tubule cell proliferation. Exposure to light chains for 48 hours caused dose-dependent inhibition in tritium ((3)H)-thymidine incorporation by simian virus 40 immortalized human proximal tubule cells, although the effect was variable among different species of light chains. We studied cytotoxic effects of selected toxic light chains in further detail. Two of these light chains caused significant DNA… CONTINUE READING

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