Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.

Abstract

The role of cytochrome P450 (P450) in the cytotoxicity of mitomycin C (MMC) and Adriamycin (ADR) was investigated in freshly isolated hepatocytes from phenobarbital-induced rats. The loss of cell viability [measured as lactate dehydrogenase (LDH) leakage] upon MMC exposure was accompanied by a rapid and extensive intracellular glutathione (GSH) depletion… (More)

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@article{Goeptar1994CytotoxicityOM, title={Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.}, author={Arnold R. Goeptar and Evelyn Groot and Heleen Scheerens and J. N. M. Commandeur and N. P. E. Vermeulen}, journal={Cancer research}, year={1994}, volume={54 9}, pages={2411-8} }