Cytotoxicity of fumonisin B1: implication of lipid peroxidation and inhibition of protein and DNA syntheses

@article{AbadoBecognee1998CytotoxicityOF,
  title={Cytotoxicity of fumonisin B1: implication of lipid peroxidation and inhibition of protein and DNA syntheses},
  author={Karine Abado-Becognee and Th{\'e}ophile Amondo Mobio and Rachid Ennamany and Francis Fleurat-Lessard and Wayne Thomas Shier and Farid Abdel-Rahem Badria and Edmond Eku{\'e} Creppy},
  journal={Archives of Toxicology},
  year={1998},
  volume={72},
  pages={233-236}
}
The effects of fumonisin B1 (FB1) from Fusarium moniliforme on lipid peroxidation and protein and DNA syntheses were studied in monkey kidney cells (Vero cells). FB1 was found to be a potent inducer of malondialdehyde (MDA), one of the secondary products formed during lipid peroxidation. At 0.14 μM (0.1 μg/ml), FB1 induced 0.496 ± 0.1 nmoles of MDA/mg protein, compared to the control level 0.134 ± 0.01 nmoles of MDA/mg protein (P < 0.005). No inhibition of protein or DNA synthesis was observed… CONTINUE READING