Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels.

@article{Lee2010CytotoxicityOC,
  title={Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels.},
  author={T Lee and C C Hu and S Lee and M-Y Chou and Yeun-Chung Chang},
  journal={International endodontic journal},
  year={2010},
  volume={43 5},
  pages={430-5}
}
AIM To evaluate the mechanisms of cytotoxicity of chlorhexidine (CHX) in human osteoblastic cells in vitro. METHODOLOGY Cytotoxicity, cell proliferation and collagen synthesis assays were performed to elucidate the toxic effects of CHX on the human osteoblastic cell line U2OS. To determine whether glutathione (GSH) levels were important in the cytotoxicity of CHX, cells were pre-treated with 2-oxothiazolidine-4-carboxylic acid (OTZ) to boost GSH levels or buthionine sulfoximine (BSO) to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…