Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content.

@article{Durgo2013CytotoxicityOB,
  title={Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content.},
  author={Ksenija Durgo and Mladen Kon{\vc}ar and Dra{\vz}enka Komes and Ana Bel{\vs}{\vc}ak-Cvitanovi{\'c} and Jasna Franeki{\'c} and Ivan Jakopovich and Neven Jakopovich and Boris Jakopovich},
  journal={International journal of medicinal mushrooms},
  year={2013},
  volume={15 5},
  pages={
          435-48
        }
}
The use of mushrooms contributes to human nutrition by providing low lipid content of lipids and high dietary fiber content, as well as significant content of other biologically active compounds such as polysaccharides, minerals, vitamins, and polyphenolic antioxidants. This study aimed to determine the content of polyphenols and polysaccharides, as well as the cytotoxic and antioxidative properties of several medicinal mushroom preparations. The content of total phenols and flavonoids of… 
Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans
TLDR
The chemistry of mushroom polysaccharides and their reported antiobesity and antidiabetic properties as well as selected anticarcinogenic, antimicrobial, and antiviral effects that demonstrate their multiple health-promoting potential are surveyed.
Antiproliferative and Antioxidant Activities of Wild Boletales Mushrooms from France.
TLDR
It is necessary to identify bioactive compounds and to valorize the mushrooms-for edible species, directly as health foods, or, for inedible mushrooms, as ingredients in the pharmaceutical and food industries.
IN-VITRO EVALUATION OF ANTI-CANCER PROPERTY OF FOUR EDIBLE MUSHROOMS IN COMPARISON WITH GANODERMA LUCIDUM : THE KING OF MEDICINAL MUSHROOMS
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TLDR
A significant antiproliferative and pro-apoptotic effect of tested medicinal mushroom preparations on colorectal cancer cell lines is found, while the effect on human fibroblast cell line was proliferative emphasizing a specificity towards tumor cell lines.
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The physiological relevance of the polysaccharides, the underlying mechanism, and hurdles in the path of their therapeutics transition, have been discussed and critical comments have been made to expedite research in this area.
Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms
TLDR
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Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk.
TLDR
The results indicated that T1 and T6 strains of TFs showed the similar immune modulatory and anticancer abilities were better than the CH strain ofTFs.
Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties
TLDR
It has been proved that both crude extracts and the compounds isolated from F. officinalis have a wide spectrum of therapeutic effects, including anti‐inflammatory, cytotoxic, and antimicrobial effects.
Characterization and applications of mushroom exopolysaccharides
Abstract A diverse group of polysaccharides with structural complexity are known to be synthesized by microorganisms. The polysaccharides either are found attached on the cell surface or remain in
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References

SHOWING 1-10 OF 32 REFERENCES
Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities
TLDR
Based on the findings, culinary-medicinal mushrooms can be considered as potential source of dietary antioxidant and ACE inhibitory agents.
Pro- and Antioxidative Properties of Medicinal Mushroom Extracts
TLDR
It is suggested that possible excess cell defense?related intracellular ROS generated by mushroom extracts may be downregulated by the antioxidant components present in the same extracts.
Biomolecule Profiles in Inedible Wild Mushrooms with Antioxidant Value
TLDR
Fomitopsis pinicola revealed a very high phenolics concentration and powerful antioxidant properties, mainly reducing power (EC50 value 60 μg/mL similar to the standard Trolox®), which could find applications in the prevention of free radical-related diseases as a source of bioactive compounds.
Phenolic compounds present in medicinal mushroom extracts generate reactive oxygen species in human cells in vitro
Hot-water extracts of the higher Basidiomycetes Agaricus bisporus (J. Lge) Imbach, A. brasiliensis S. Wasser et al., Coprinus comatus (O.F. Mull.) Pers., Ganoderma lucidum (W. Curt.: Fr.) P. Karst.,
Antioxidant activity and toxicity profile of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst occurring in South India.
TLDR
The ability of total triterpenes to scavenge the free radicals and to enhance body's antioxidant defence systems indicates its potential use as an antioxidant.
Protective effect of polysaccharide-protein complex from a polypore mushroom, Phellinus rimosus against radiation-induced oxidative stress
TLDR
Investigation of the protective effect of polysaccharide protein complex isolated from the mushroom Phellinus rimosus against the oxidative stress induced by gamma radiation indicates profound effects of PPC-Pr against radiation-induced oxidative stress and suggests potential therapeutic use of P PC-Pr in radiotherapy.
Antioxidant activity applying an improved ABTS radical cation decolorization assay.
A method for the screening of antioxidant activity is reported as a decolorization assay applicable to both lipophilic and hydrophilic antioxidants, including flavonoids, hydroxycinnamates,
Protective effects of new medicinal mushroom, Grifola gargal singer (higher Basidiomycetes), on induced DNA damage in somatic cells of Drosophila melanogaster.
TLDR
Protective effects of G. gargal against DMBA are discussed in terms of the onset of desmutagenic and/or bioantimutagenic mechanisms of detoxification in the host organism, probably due to some bioactive compounds known to occur in higher mushrooms.
The Influence of Medicinal Mushroom Preparations on Mouse Tumors
TLDR
The findings that the mushroom preparation tested induced a selective inhibition of tumor cell proliferation observed in vitro and a pronounced prolongation of the survival rate of tumor-bearing mice are of particular interest.
In vitro fermentation characteristics of two mushroom species, an herb, and their polysaccharide fractions, using chicken cecal contents as inoculum.
TLDR
These medicinal mushroom and herb materials, particularly their polysaccharide extracts, show promise in altering microbial activities and composition in chicken ceca as well as differences in availability of substrates between the mushrooms and herb.
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