Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study.

@article{Onderwater1998CytotoxicityOA,
  title={Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study.},
  author={Rob C. A. Onderwater and Jan N M Commandeur and E. J. Groot and A. Sitters and Wiro M.P.B Menge and Nico P. E. Vermeulen},
  journal={Toxicology},
  year={1998},
  volume={125 2-3},
  pages={
          117-29
        }
}
The cytotoxicity of a series of 12 mono- and 4 di-substituted thiourea containing compounds in freshly isolated rat hepatocytes was investigated. It was found that thiourea toxicity, as evidenced by an increase in LDH-leakage from the cells, was accompanied by a depletion of intracellular glutathione (GSH). No increase in lipid peroxidation was observed with any of the thiourea. Burimamide and thioperamide, thiourea-containing histamine receptor ligands, were also found to deplete intracellular… Expand
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