Cytotoxicity of Vinca minor

@article{Khanavi2010CytotoxicityOV,
  title={Cytotoxicity of Vinca minor},
  author={Mahnaz Khanavi and Shabnam Pourmoslemi and Behnaz Farahanikia and Abbas Hadjiakhoondi and Seyed Nasser Ostad},
  journal={Pharmaceutical Biology},
  year={2010},
  volume={48},
  pages={100 - 96}
}
Vinca minor L. (Apocynaceae) is a medicinal plant that has long been used to treat cerebral and memory disorders in European folk medicine. Furthermore, it contains more than 50 alkaloids, some of them having bisindole structure such as the antineoplastic alkaloids present in Catharanthus roseus (L.) G. Don (Apocynaceae). In this study, the plant’s alkaloid extract was divided into three fractions and the cytotoxic effects on cell proliferation of HT-29, Caco-2, T47D, and NIH/3T3 cell lines… 
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References

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TLDR
Vincadifformine, which was found to inhibit most significantly the biochemical functions of P388 cells of all monomers under study, stopped the proliferation of cells in vitro in a 50 micrograms X ml-1 concentration even after 12 h of action.
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TLDR
This review focuses on the eburnamine structures with cerebral activities in this class of alkaloids, and proves vinpocetine's clinical usefulness in the treatment of post‐ischaemic stroke disease states and various disorders of cerebrovascular origin.
Proteome Analysis of Vinca Alkaloid Response and Resistance in Acute Lymphoblastic Leukemia Reveals Novel Cytoskeletal Alterations*
TLDR
Novel insights are provided into the interrelationship between the microtubule and microfilament systems in vinca alkaloid resistance and novel targets for elucidation of resistance mechanisms are identified.
Regulation of Vinca alkaloid-induced apoptosis by NF-κB/IκB pathway in human tumor cells
TLDR
It is found that glucocorticoids inhibit Vinca alkaloid-induced apoptosis without affecting G2-M arrest in human breast cancer BCap37 cells and human epidermoid tumor KB cells, suggesting that Vincas alkaloids' apoptosis may occur via a pathway independent of cell cycle arrest.
Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine.
TLDR
Despite differences in their actions on individual dynamic instability parameters, morphologically detectable differences in spindle effects among the three drugs were minimal, indicating that overall suppression of dynamics may be more important in blocking mitosis than specific effects on growth or shortening.
Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells.
TLDR
It is found that glucocorticoids inhibit Vinca alkaloid-induced apoptosis without affecting G(2)-M arrest in human breast cancer BCap37 cells and human epidermoid tumor KB cells, suggesting that VincA alkaloids' apoptosis may occur via a pathway independent of cell cycle arrest.
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TLDR
This article suggests why now, with the presently available technology, and the remaining biome available and reasonably accessible, is an opportune moment to consciously focus on the discovery of further alkaloids with pharmacophoric utility.
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TLDR
Disruption of microtubule structure by antimicrotubule drugs results in induction of tumor suppressor gene p53 and inhibitor of cyclin-dependent kinases, p21WAF1/CIP1 (p21), and activation/inactivation of several protein kinases including Ras/Raf, PKC/PKA I/II, MAP kinases and p34cdc2.
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TLDR
Results show that taxol, vincristine and vindesine behave similarly in their ability to reduce the capillary network formation by HUVEC cells cultured on Matrigel, and anti-angiogenic effects appear at non-cytotoxic concentrations.
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