Cytotoxicity of Vinca minor

  title={Cytotoxicity of Vinca minor},
  author={Mahnaz Khanavi and Shabnam Pourmoslemi and Behnaz Farahanikia and Abbas Hadjiakhoondi and Seyed Nasser Ostad},
  journal={Pharmaceutical Biology},
  pages={100 - 96}
Vinca minor L. (Apocynaceae) is a medicinal plant that has long been used to treat cerebral and memory disorders in European folk medicine. Furthermore, it contains more than 50 alkaloids, some of them having bisindole structure such as the antineoplastic alkaloids present in Catharanthus roseus (L.) G. Don (Apocynaceae). In this study, the plant’s alkaloid extract was divided into three fractions and the cytotoxic effects on cell proliferation of HT-29, Caco-2, T47D, and NIH/3T3 cell lines… 
Phytochemical Investigation of Vinca minor Cultivated in Iran
This plant may be used as a natural source for pharmaceutical purposes in Iran, due to the presence of biologically active alkaloids especially vincamine as the major alkaloid in Lesser Periwinkle cultivated.
The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects
The Vinca extracts acted in a dose-depended manner against HaCaT keratinocytes and A375 melanoma cells and moreover, with effects on the ultrastructure, nitric oxide concentration, and lactate dehydrogenase release, which could be exploited further for the development of alternative treatments in bacterial infections or as anticancer adjuvants.
Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine
The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.
In vitro cytotoxic, antioxidative and alpha-glucosidase inhibitory potential of a herbal mixture comprised of Allium sativum and Lagerstroemia speciosa.
The cytotoxic effects of ASE, LSE and their combination in the ratio of 1:2, 1:1 w/w were evaluated using 3T3 L1 preadipocyte cells and the results observed with lactate dehydrogenase (LDH) release were similar to that of cell viability assay.
This study investigated the antimicrobial activity as well as some phytochemical analysis of ethanol and diethyl ether extracts from plant species Vinca minor L. minor to determine the amount of total phenolics, flavonoids and tannins and the determination of antioxidan t activity monitoring capability to neutralize free radicals.
Antimicrobial and antibiofilm activities of secondary metabolites from Vinca minor L.
The aim of study was to investigate the antimicrobial and antibiofilm activities as well as chemical analysis of aquatic, acetone and ethyl acetate extracts Vinca minor L. collected in Balkan


New compounds with cytotoxic and antitumor effects. Part 6: Monomeric indole alkaloids of vinca minor L. and their effect on P388 cells.
Vincadifformine, which was found to inhibit most significantly the biochemical functions of P388 cells of all monomers under study, stopped the proliferation of cells in vitro in a 50 micrograms X ml-1 concentration even after 12 h of action.
Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: in vitro and in vivo study.
Eburnamine derivatives and the brain
This review focuses on the eburnamine structures with cerebral activities in this class of alkaloids, and proves vinpocetine's clinical usefulness in the treatment of post‐ischaemic stroke disease states and various disorders of cerebrovascular origin.
Proteome Analysis of Vinca Alkaloid Response and Resistance in Acute Lymphoblastic Leukemia Reveals Novel Cytoskeletal Alterations*
Novel insights are provided into the interrelationship between the microtubule and microfilament systems in vinca alkaloid resistance and novel targets for elucidation of resistance mechanisms are identified.
Regulation of Vinca alkaloid-induced apoptosis by NF-κB/IκB pathway in human tumor cells
It is found that glucocorticoids inhibit Vinca alkaloid-induced apoptosis without affecting G2-M arrest in human breast cancer BCap37 cells and human epidermoid tumor KB cells, suggesting that Vincas alkaloids' apoptosis may occur via a pathway independent of cell cycle arrest.
Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine.
Despite differences in their actions on individual dynamic instability parameters, morphologically detectable differences in spindle effects among the three drugs were minimal, indicating that overall suppression of dynamics may be more important in blocking mitosis than specific effects on growth or shortening.
Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells.
It is found that glucocorticoids inhibit Vinca alkaloid-induced apoptosis without affecting G(2)-M arrest in human breast cancer BCap37 cells and human epidermoid tumor KB cells, suggesting that VincA alkaloids' apoptosis may occur via a pathway independent of cell cycle arrest.
The potential of alkaloids in drug discovery
This article suggests why now, with the presently available technology, and the remaining biome available and reasonably accessible, is an opportune moment to consciously focus on the discovery of further alkaloids with pharmacophoric utility.
The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review
Disruption of microtubule structure by antimicrotubule drugs results in induction of tumor suppressor gene p53 and inhibitor of cyclin-dependent kinases, p21WAF1/CIP1 (p21), and activation/inactivation of several protein kinases including Ras/Raf, PKC/PKA I/II, MAP kinases and p34cdc2.
In vitro pharmacological characterizations of the anti-angiogenic and anti-tumor cell migration properties mediated by microtubule-affecting drugs, with special emphasis on the organization of the actin cytoskeleton.
Results show that taxol, vincristine and vindesine behave similarly in their ability to reduce the capillary network formation by HUVEC cells cultured on Matrigel, and anti-angiogenic effects appear at non-cytotoxic concentrations.