Cytotoxicity of TBBPA and effects on proliferation, cell cycle and MAPK pathways in mammalian cells.

@article{Strack2007CytotoxicityOT,
  title={Cytotoxicity of TBBPA and effects on proliferation, cell cycle and MAPK pathways in mammalian cells.},
  author={Siegfried Strack and Tanja Detzel and Markus Wahl and Bertram Kuch and Harald F Krug},
  journal={Chemosphere},
  year={2007},
  volume={67 9},
  pages={S405-11}
}
Poly-brominated flame retardants are ecotoxicologically relevant chemicals that can show high persistency in environmental samples and bioaccumulation in marine and fresh water animals. One of the most widely used compound is tetrabromobisphenol A (TBBPA). Until today, the toxicological data are rather fragmentary. Our studies on acute and sub-acute toxic effects with established cell lines demonstrate that TBBPA interferes with cellular signaling pathways. Cell viability is significantly… CONTINUE READING