Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.

@article{Tudor2005CytotoxicityOR,
  title={Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.},
  author={G. Tudor and Mike Alley and Christopher M. Nelson and Ruili Huang and David G. Covell and Peter Gutierrez and Edward A. Sausville},
  journal={Anti-cancer drugs},
  year={2005},
  volume={16 4},
  pages={381-91}
}
The elevated expression of the flavoprotein NAD(P)H:quinone acceptor oxidoreductase (NQO1) (EC 1.6.99.2) in many human solid tumors, along with its ability to activate quinone-based anticancer agents, makes it an excellent target for enzyme-directed drug development. Previous studies have shown a significant statistical correlation between NQO1 enzymatic activity and the cytotoxicity of certain antitumor quinones. RH1 [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone], presently in… CONTINUE READING
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