Cytotoxicity of Amrubicin, a Novel 9‐Aminoanthracycline, and Its Active Metabolite Amrubicinol on Human Tumor Cells

@inproceedings{Yamaoka1998CytotoxicityOA,
  title={Cytotoxicity of Amrubicin, a Novel 9‐Aminoanthracycline, and Its Active Metabolite Amrubicinol on Human Tumor Cells},
  author={Takashi Yamaoka and Mituharu Hanada and Shinji Ichii and Shinya Morisada and Toshihiro Noguchi and Yoshikazu Yanagi},
  booktitle={Japanese journal of cancer research : Gann},
  year={1998}
}
Amrubicin, a completely synthetic 9-aminoanthracycline derivative, was previously shown to have potent antitumor activities against various human tumor xenografts. In this study, the in vitro activities of amrubicin and its major metabolite, amrubicinol, were examined using 17 human tumor cell lines. Amrubicinol was 5 to 54 times more potent than amrubicin, and as potent as doxorubicin, in inhibiting the growth of the cells following 3-day continuous drug exposure. Amrubicinol closely resembled… CONTINUE READING
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