Cytotoxicity mediated by the Fas ligand (FasL)-activated apoptotic pathway in stem cells.

  title={Cytotoxicity mediated by the Fas ligand (FasL)-activated apoptotic pathway in stem cells.},
  author={Julia Mazar and Molly Thomas and Ludmila Bezrukov and Alexander Chanturia and Gulçin Pekkurnaz and Shurong Yin and Sergei Kuznetsov and Pamela Robey and Joshua Zimmerberg},
  journal={The Journal of biological chemistry},
  volume={284 33},
Whereas it is now clear that human bone marrow stromal cells (BMSCs) can be immunosuppressive and escape cytotoxic lymphocytes (CTLs) in vitro and in vivo, the mechanisms of this phenomenon remain controversial. Here, we test the hypothesis that BMSCs suppress immune responses by Fas-mediated apoptosis of activated lymphocytes and find both Fas and FasL expression by primary BMSCs. Jurkat cells or activated lymphocytes were each killed by BMSCs after 72 h of co-incubation. In comparison, the… CONTINUE READING
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