Cytotoxicity mechanisms of sodium hypochlorite in cultured human dermal fibroblasts and its bactericidal effectiveness.

@article{Hidalgo2002CytotoxicityMO,
  title={Cytotoxicity mechanisms of sodium hypochlorite in cultured human dermal fibroblasts and its bactericidal effectiveness.},
  author={Eduard Hidalgo and Rosa Mar{\'i}a Bartolom{\'e} and Carmen Dom{\'i}nguez},
  journal={Chemico-biological interactions},
  year={2002},
  volume={139 3},
  pages={265-82}
}
We investigated the therapeutic efficacy of the topical antiseptic sodium hypochlorite (NaOCl) for antibacterial activity and in parallel the cytotoxicity mechanisms by which hypochlorite and the chloramines generated therefrom induce oxidative tissue damage, which further influences the wound-healing process. Human dermal fibroblasts were exposed to increasing concentrations of reagent NaOCl (0.00005-0.1%) at exposure times varying between 2 and 24 h and the protective effects of fetal calf… CONTINUE READING
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