Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents.

@article{Eagle1958CytotoxicityIH,
  title={Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents.},
  author={Harry Eagle and George E. Foley},
  journal={Cancer research},
  year={1958},
  volume={18 9},
  pages={1017-25}
}
It has been shown in a preceding paper (5) that thirteen agents known to have an anti-tumor effect in animals or man were highly cytotoxic against a number of cultured human and animal cells, inhibiting growth at concentrations of 10~5 to 10~9 M. Conversely, two folie acid analogs which were essentially devoid of anti-tumor action in vivo were relatively inactive in cell cultures. These findings suggested that the "anti-tumor" 
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Eventuale azione di alcuni inibitori della catalasi sulla cancerogenesi cutanea da 3,4-benzopirene nel topa

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American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from 1958;18:1017-1025

  • J. H. WILLIAMS
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  • 1951

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