Cytotoxicity evaluation of sodium alendronate on cultured human periodontal ligament fibroblasts.

@article{Correia2006CytotoxicityEO,
  title={Cytotoxicity evaluation of sodium alendronate on cultured human periodontal ligament fibroblasts.},
  author={Vera de F{\'a}tima Padr{\~a}o Correia and Celso Luiz Caldeira and M{\'a}rcia Martins Marques},
  journal={Dental traumatology : official publication of International Association for Dental Traumatology},
  year={2006},
  volume={22 6},
  pages={312-7}
}
External root resorption processes are usually associated with dental trauma, mainly avulsion and intrusion. In such cases endodontic therapy aims to prevent this process by using medications that can inhibit osteoclastic activity, such as bisphosphonates. However, these drugs must be biocompatible to the periapical tissues. The aim of this study was to analyze the cytotoxicity of a bisphosphonate (sodium alendronate) on human periodontal ligament fibroblasts (PDL cells). Cells were plated in a… CONTINUE READING