Cytotoxicity evaluation of ceramic particles of different sizes and shapes.

  title={Cytotoxicity evaluation of ceramic particles of different sizes and shapes.},
  author={Akiko Yamamoto and Rieko Honma and Masae Sumita and Takao Hanawa},
  journal={Journal of biomedical materials research. Part A},
  volume={68 2},
When artificial hip or knee joints are implanted in the human body, they release metallic, ceramic, and polymeric debris into the surrounding tissues. The toxicity of the released particles is of two types: chemical, caused by the released soluble ions and monomers, and mechanical, a result of mechanical stimulation produced by the insoluble particles. In this study, the cytotoxicity of particles of TiO2, Al2O3, ZrO2, Si3N4, and SiC for murine fibroblasts and macrophages were examined to… CONTINUE READING


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