Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells.

@article{Macedo2019CytotoxicityAS,
  title={Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells.},
  author={A. Macedo and D. P. da Silva and D. Moreira and Lucas N de Queiroz and T. Vasconcelos and G. F. Araujo and M. A. Kaplan and S. S. Pereira and Elan C P de Almeida and A. Valverde and B. K. Robbs},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2019},
  volume={110},
  pages={
          342-352
        }
}
BACKGROUND Oral squamous cell carcinoma (OSCC) is one of the ten most common types of cancer worldwide. Plants of the genusPiper are used in traditional medicine to treat cancer, and they have a vast diversity of phytochemicals with cytotoxic potential. Purpose and Study Design: In this work, we analyzed the cytotoxic and selective potential of extracts and semipurified fractions of Piper mollicomum (PM), Piper truncatum (PT), Piper cernuum (PC), Piper arboreum (PA), and Piper cabralanum (PCa… Expand
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References

SHOWING 1-10 OF 45 REFERENCES
(-)-Kusunokinin and piperloguminine from Piper nigrum: An alternative option to treat breast cancer.
TLDR
The results suggest that the (-)-kusunokinin and piperlonguminine have been shown to have potent anticancer activities through extrinsic pathway and G2/M phase arrest. Expand
Potential cytotoxic and selective effect of new benzo[b]xanthenes against oral squamous cell carcinoma.
TLDR
The xanthene-naphthoquinone derivatives show promising bioactivity for oral cavity cancer treatment. Expand
Assessment of cytotoxicity and genotoxicity of stem bark extracts from Canarium odontophyllum Miq. (dabai) against HCT 116 human colorectal cancer cell line
TLDR
Acetone extract from stem bark of C. odontophyllum has high potential in the development of anticancer agent against HCT 116 cells with no cytotoxic effect against human colon fibroblast cells. Expand
Chemical Composition and in vitro Cytotoxic and Antileishmanial Activities of Extract and Essential Oil from Leaves of Piper cernuum
TLDR
The crude essential oil and compounds 7-10 reduced parasitism and eliminated the majority of infected and non-infected cells at 50μg/mL, and Evaluation against non-tumorigenic HFF cells indicated a reduced selectivity of compounds 6-10 to tumoral cells. Expand
Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants
TLDR
Piplartine (piperlongumine) shows the most promise, being toxic to dozens of cancer cell lines and having excellent in vivo activity, and it is worthwhile to conduct further anticancer studies both in vitro and in vivo on Piper plants and their active principles. Expand
Cytotoxic constituents from Hyptis verticillata.
TLDR
A new cytotoxic arylnaphthalene lignan has been isolated from the Mexican medicinal plant Hyptis verticillata and characterized as 5-methoxydehydropodophyllotoxin, and the antimitotic potential of these compounds was determined in the astrocytoma (ASK) assay. Expand
A systematic review on ethnomedicines of anti‐cancer plants
TLDR
Results indicated that traditional medicines are mostly being use in developing countries for cancer treatment and Traditionally and scientifically skin and breast cancer types gained more focus. Expand
Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: Cytological studies and chemical investigations
TLDR
Findings suggest that yatein may be of potential pharmacological interest and warrants further investigation in human cell lines, as it could have similar cytoplasmic target(s) such as the microtubular apparatus. Expand
Antioxidant Capacity and Larvicidal and Antifungal Activities of Essential Oils and Extracts from Piper krukoffii
TLDR
The leaves and twigs of Piper krukoffii, collected in the Carajás National Forest, north Brazil, yielded essential oils and methanol extract, the main constituents of which were myristicin and apiole, indicating a significant antioxidant activity for the plant. Expand
Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents.
TLDR
A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells and led to the isolation of two known lignans and a new lignan, (-)-cubebinin. Expand
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