Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells.

  title={Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells.},
  author={A. Macedo and D. P. da Silva and D. Moreira and Lucas N de Queiroz and T. Vasconcelos and G. F. Araujo and M. A. Kaplan and S. S. Pereira and Elan C P de Almeida and A. Valverde and B. K. Robbs},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
BACKGROUND Oral squamous cell carcinoma (OSCC) is one of the ten most common types of cancer worldwide. Plants of the genusPiper are used in traditional medicine to treat cancer, and they have a vast diversity of phytochemicals with cytotoxic potential. Purpose and Study Design: In this work, we analyzed the cytotoxic and selective potential of extracts and semipurified fractions of Piper mollicomum (PM), Piper truncatum (PT), Piper cernuum (PC), Piper arboreum (PA), and Piper cabralanum (PCa… Expand
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Black pepper and piperine induce anticancer effects on leukemia cell line.
The molecular docking studies showed the binding of PIP with PCNA and Bcl-2 and supported the in vitro findings, and methanolic extract of black pepper and pure piperine showed a strong cytotoxic effect against this cell line. Expand
Molecular mechanism of action of new 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles with cytotoxic and selective effect against oral squamous cell carcinoma.
Among the 35 synthesized triazole naphthoquinones, compound 16 g was the most effective compound against OSCC cells, presenting high cytotoxicity, selectivity, and low acute toxicity on animals, and therefore might be considered for future cancer therapy. Expand
Anticancer Potential of Dietary Natural Products: A Comprehensive Review.
  • Rumana Ahmad, Mohsin A. Khan, +7 authors Arvind K. Srivastava
  • Medicine, Biology
  • Anti-cancer agents in medicinal chemistry
  • 2019
The present review provides a comprehensive and collective update on the potential of 65 commonly used spices as well as their bioactive constituents as anticancer agents. Expand
Cytotoxic Influence of Khat (Catha edulis (Vahl) Forssk. ex Endl) on Oral Fibroblasts, Squamous Carcinoma Cells, and Expression of α Smooth Muscle Actin
The aim was to determine the cytotoxicity of Khat (Catha edulis (Vahl) Forssk. ex Endl) on normal oral fibroblasts (NOFs) and SCC4 (squamous carcinoma cells) along with expression of α-smooth muscleExpand
Histopathological, cytotoxicological, and genotoxic effects of the semi-synthetic compound dillapiole n-butyl ether in Balb/C mice
Dillapiole n-butyl ether has insecticidal and genotoxic effects on A. aegypti and A. albopictus, as shown by the reduction in clutch size and egg viability, and increased mortality rates, as well as a high frequency of micronuclei and chromosomal aberrations. Expand
Antiparasitic effects of ethanolic extracts of Piper arboreum and Jatropha gossypiifolia leaves on cercariae and adult worms of Schistosoma mansoni
For the first time, it was proven that ethanolic extracts of P. arboreum and J. gossypiifolia leaves are biologically active against cercariae and adult worms of S. mansoni in vitro. Expand
1H and 13C NMR Spectral Data of Neolignans Isolated from Piper Species
Plants of the genus Piper (Piperaceae) have a pantropical distribution. In Brazil, Piper species are used in traditional medicine to treat many diseases such as inflammation, diabetes, toothache,Expand
Chemical composition of the essential oils of circadian rhythm and of different vegetative parts from Piper mollicomum Kunth - A medicinal plant from Brazil
There are great differences in the EOs composition, considering phenology, seasonality and vegetative parts of P. mollicomum, and in the circardian rhythm study, EOs showed to be rich in 1,8-cienol and/or linalool in accordance with season and phenology. Expand
S003118202000181Xjra 1689..1699
  • 2020


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The results suggest that the (-)-kusunokinin and piperlonguminine have been shown to have potent anticancer activities through extrinsic pathway and G2/M phase arrest. Expand
Potential cytotoxic and selective effect of new benzo[b]xanthenes against oral squamous cell carcinoma.
The xanthene-naphthoquinone derivatives show promising bioactivity for oral cavity cancer treatment. Expand
Assessment of cytotoxicity and genotoxicity of stem bark extracts from Canarium odontophyllum Miq. (dabai) against HCT 116 human colorectal cancer cell line
Acetone extract from stem bark of C. odontophyllum has high potential in the development of anticancer agent against HCT 116 cells with no cytotoxic effect against human colon fibroblast cells. Expand
Chemical Composition and in vitro Cytotoxic and Antileishmanial Activities of Extract and Essential Oil from Leaves of Piper cernuum
The crude essential oil and compounds 7-10 reduced parasitism and eliminated the majority of infected and non-infected cells at 50μg/mL, and Evaluation against non-tumorigenic HFF cells indicated a reduced selectivity of compounds 6-10 to tumoral cells. Expand
Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants
Piplartine (piperlongumine) shows the most promise, being toxic to dozens of cancer cell lines and having excellent in vivo activity, and it is worthwhile to conduct further anticancer studies both in vitro and in vivo on Piper plants and their active principles. Expand
Cytotoxic constituents from Hyptis verticillata.
A new cytotoxic arylnaphthalene lignan has been isolated from the Mexican medicinal plant Hyptis verticillata and characterized as 5-methoxydehydropodophyllotoxin, and the antimitotic potential of these compounds was determined in the astrocytoma (ASK) assay. Expand
A systematic review on ethnomedicines of anti‐cancer plants
Results indicated that traditional medicines are mostly being use in developing countries for cancer treatment and Traditionally and scientifically skin and breast cancer types gained more focus. Expand
Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: Cytological studies and chemical investigations
Findings suggest that yatein may be of potential pharmacological interest and warrants further investigation in human cell lines, as it could have similar cytoplasmic target(s) such as the microtubular apparatus. Expand
Antioxidant Capacity and Larvicidal and Antifungal Activities of Essential Oils and Extracts from Piper krukoffii
The leaves and twigs of Piper krukoffii, collected in the Carajás National Forest, north Brazil, yielded essential oils and methanol extract, the main constituents of which were myristicin and apiole, indicating a significant antioxidant activity for the plant. Expand
Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents.
A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells and led to the isolation of two known lignans and a new lignan, (-)-cubebinin. Expand