Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepatocytes.

Abstract

Some N-alkylformamides such as N-methylformamide (NMF) possess hepatotoxic properties in vivo. To study the mechanism of this toxicity, suspensions of mouse hepatocytes were tested as an in vitro model system suitable for the study of the relationship between (i) the toxic potential of formamides, (ii) their metabolism to N-alkylcarbamoylating species, and… (More)

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