Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepatocytes.


Some N-alkylformamides such as N-methylformamide (NMF) possess hepatotoxic properties in vivo. To study the mechanism of this toxicity, suspensions of mouse hepatocytes were tested as an in vitro model system suitable for the study of the relationship between (i) the toxic potential of formamides, (ii) their metabolism to N-alkylcarbamoylating species, and… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics