Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents.

@article{Cimanga2006CytotoxicityAI,
  title={Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents.},
  author={Richard K Cimanga and Kabangu Kambu and Lutete Tona and Nina Hermans and Sandra Apers and Jozef Tott{\'e} and Luc Pieters and Arnold J. Vlietinck},
  journal={Journal of ethnopharmacology},
  year={2006},
  volume={107 1},
  pages={83-90}
}
An aqueous decotion (dried extract), an 80% MeOH extract from Morinda morindoides leaves, and 10 flavonoids and 4 iridoids isolated from the 80% MeOH extract were evaluated in vitro for their potential antiamoebic activity and their cytotoxic effect against MT-4 cells. Results indicated that the aqueous decoction and the 80% MeOH extract exhibited an interesting antiamoebic activity with IC(50) values of 3.1 +/- 1.7 and 1.7 +/- 0.6 microg/ml, respectively. Apigenin-7-O-glucoside and luteolin-7… CONTINUE READING