Cytotoxicity and chemosensitizing activity of amphiphilic poly(glycerol)-poly(alkylene oxide) block copolymers.

@article{Demina2014CytotoxicityAC,
  title={Cytotoxicity and chemosensitizing activity of amphiphilic poly(glycerol)-poly(alkylene oxide) block copolymers.},
  author={Tatiana V Demina and Olga A Budkina and Gennadii A. Badun and Nickolay S Melik-Nubarov and Holger Frey and Sophie S M{\"u}ller and J{\"o}rg Nieberle and I Grozdova},
  journal={Biomacromolecules},
  year={2014},
  volume={15 7},
  pages={2672-81}
}
All polymeric chemosensitizers proposed thus far have a linear poly(ethylene glycol) (PEG) hydrophilic block. To testify whether precisely this chemical structure and architecture of the hydrophilic block is a prerequisite for chemosensitization, we tested a series of novel block copolymers containing a hyperbranched polyglycerol segment as a hydrophilic block (PPO-NG copolymers) on multi-drug-resistant (MDR) tumor cells in culture. PPO-NG copolymers inhibited MDR of three cell lines… CONTINUE READING

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