Cytotoxicity and apoptosis in human renal allografts: identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA.

@article{Meehan1997CytotoxicityAA,
  title={Cytotoxicity and apoptosis in human renal allografts: identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA.},
  author={Shane M. Meehan and Robert T. McCluskey and M Virginia Pascual and Frederic I. Preffer and Peter A.M. Anderson and Stuart F. Schlossman and Robert B. Colvin},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1997},
  volume={76 5},
  pages={639-49}
}
In the present study, we analyzed human renal allografts using immunohistochemical techniques to determine the site, identity, and frequency of (a) cytotoxic and apoptotic cells, as identified by staining for GMP-17 (TIA-1), a component of cytotoxic granules; and (b) DNA fragmentation in situ, as detected by the TUNEL method. In acute cellular rejection (n = 15), GMP-17+ mononuclear cells accounted for 29% +/- 12% of the infiltrating cells in the interstitium (341 +/- 164/mm2) and were… CONTINUE READING

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