Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide.

@article{Zwelling1982CytotoxicityAD,
  title={Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide.},
  author={Leonard A. Zwelling and Deanna Kerrigan and Stephanie Michaels},
  journal={Cancer research},
  year={1982},
  volume={42 7},
  pages={2687-91}
}
The effects upon cellular DNA and cytotoxicity produced by the anthracyclines 5-iminodaunorubicin and Adriamycin were studied in mouse leukemia L1210 cells. 5-Iminodaunorubicin produced protein-concealed DNA strand breaks as measured by alkaline elution as had other intercalators including Adriamycin. 5-Iminodaunorubicin produced DNA breaks more efficiently than did Adriamycin despite a lower potency for free radical formation. Many of the 5-iminodaunorubicin breaks measured in this assay may… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
5-Iminodaunorubicin produced breaks which disappeared within 1 to 2 hr following drug removal and were in this way similar to the breaks produced by the acridine intercalator 4'-(9-acridinylamino)methanesulfon - m - anisidide .
AnthracyclinesChemical structure ofDoxorubicin
The effects upon cellular DNA and cytotoxicity produced by the anthracyclines 5-iminodaunorubicin and Adriamycin were studied in mouse leukemia L1210 cells .
All Topics