Cytotoxicity and DNA-damage in human lung epithelial cells exposed to respirable α-quartz

@article{Fanizza2007CytotoxicityAD,
  title={Cytotoxicity and DNA-damage in human lung epithelial cells exposed to respirable $\alpha$-quartz},
  author={C. Fanizza and C. L. Ursini and E. Paba and A. Ciervo and A. D. Francesco and R. Maiello and P. Simone and D. Cavallo},
  journal={Toxicology in Vitro},
  year={2007},
  volume={21},
  pages={586-594}
}
Abstract Occupational exposure to respirable crystalline silica is associated with the development of silicosis, lung cancer and airways diseases. In order to assess cytotoxic effects and direct–oxidative DNA damage induced by short-term exposure to different doses of respirable α-quartz (NIST SRM1878a), we conducted a study using A549 cells. The cells were exposed to α-quartz at 25, 50, 100 μg/ml for 4 h and analysed by scanning electron microscope (SEM) and LDH release assay for cytotoxic… Expand
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