• Corpus ID: 212542382

Cytotoxicity and Antioxidant Activity of Equisetum debile Roxb. (Equisetaceae) from Bukidnon, Philippines

@inproceedings{Ang2018CytotoxicityAA,
  title={Cytotoxicity and Antioxidant Activity of Equisetum debile Roxb. (Equisetaceae) from Bukidnon, Philippines},
  author={Aileen May Gabule Ang and Nonita Picardal Peteros and Mylene M. Uy},
  year={2018}
}

• A. Ang, N. P. Peteros, M. Uy
• Published 2018

The potential of Equisetum debileRoxb. as source of lead compounds for drug development was investigated. The bioactivity of the decoction (EdD), ethanolic (EdE), chloroform(EdC), hexane (EdH), and aqueous (EdA) extracts of E. debile were determined through Brine Shrimp Lethality Test (BSLT) and in vitro antioxidant assays: Total Antioxidant Capacity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activity, and Total Phenolics Content. The chloroform extract (EdC) of E. debile exhibited moderate toxicity against Artemiasalinanauplii with an LC50 value of 190.55 mg/L and gave the highest total antioxidant capacity (354.05 mg BHT Equivalents/g sample and 330.20 mg Ascorbic Acid Equivalents/g sample). EdC also gave a remarkably higher phenolics content (713.72 mg Gallic Acid Equivalents/g sample) among the extracts, showed DPPH radical scavenging activity of 78.13% and consequently the lowest EC50 value (295.02 mg/L). The results indicated that the chloroform-soluble extract of E. debile is the most bioactive and can be further purified to identify compounds responsible for its bioactivity.