Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity

  title={Cytotoxicity Is Mandatory for CD8+ T Cell–mediated  Contact Hypersensitivity },
  author={Jeanne Kehren and Cyril Desvignes and Maya Krasteva and Marie-Th{\'e}r{\`e}se Ducluzeau and Olga M Assossou and Françoise Horand and Michael Hahne and David K{\"a}gi and Dominique Kaiserlian and Jean François Nicolas},
  journal={The Journal of Experimental Medicine},
  pages={779 - 786}
Contact hypersensitivity (CHS) is a T cell-mediated skin inflammation induced by epicutaneous exposure to haptens in sensitized individuals. We have previously reported that CHS to dinitrofluorobenzene in mice is mediated by major histocompatibility complex (MHC) class I-restricted CD8(+) T cells. In this study, we show that CD8(+) T cells mediate the skin inflammation through their cytotoxic activity. The contribution of specific cytotoxic T lymphocytes (CTLs) to the CHS reaction was examined… CONTINUE READING
78 Citations
41 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 78 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

CD81 T cells clear influenza virus by perforin or Fas-dependent processes

  • D. J. Tropham, R. A. Tripp, P. C. Doherty
  • J. Immunol
  • 1997

Hapten-peptide-T cell receptor interactions: molecular basis for the recognition of haptens by T lymphocytes

  • J. P. Lepoittevin, I. Leblond
  • Eur. J. Dermatol
  • 1997

Similar Papers

Loading similar papers…