Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity

@article{Kehren1999CytotoxicityIM,
  title={Cytotoxicity Is Mandatory for CD8+ T Cell–mediated  Contact Hypersensitivity },
  author={Jeanne Kehren and Cyril Desvignes and Maya Krasteva and Marie-Th{\'e}r{\`e}se Ducluzeau and Olga M Assossou and Françoise Horand and Michael Hahne and David K{\"a}gi and Dominique Kaiserlian and Jean François Nicolas},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={189},
  pages={779 - 786}
}
Contact hypersensitivity (CHS) is a T cell-mediated skin inflammation induced by epicutaneous exposure to haptens in sensitized individuals. We have previously reported that CHS to dinitrofluorobenzene in mice is mediated by major histocompatibility complex (MHC) class I-restricted CD8(+) T cells. In this study, we show that CD8(+) T cells mediate the skin inflammation through their cytotoxic activity. The contribution of specific cytotoxic T lymphocytes (CTLs) to the CHS reaction was examined… CONTINUE READING
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