Cytotoxicity, intracellular distribution and uptake of doxorubicin and doxorubicin coupled to cell-penetrating peptides in different cell lines: a comparative study.

@article{Aroui2010CytotoxicityID,
  title={Cytotoxicity, intracellular distribution and uptake of doxorubicin and doxorubicin coupled to cell-penetrating peptides in different cell lines: a comparative study.},
  author={Sonia Aroui and Souhir Brahim and Michel de Waard and Abderraouf Kenani},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={391 1},
  pages={
          419-25
        }
}
  • Sonia Aroui, Souhir Brahim, +1 author Abderraouf Kenani
  • Published in
    Biochemical and biophysical…
    2010
  • Biology, Medicine
  • One of the major obstacles which are opposed to the success of anticancer treatment is the cell resistance that generally develops after administration of commonly used drugs. In this study, we try to overcome the tumour cell resistance of doxorubicin (Dox) by developing a cell-penetrating peptide (CPP)-anticancer drug conjugate in aim to enhance its intracellular delivery and that its therapeutic effects. For this purpose, two cell-penetrating peptides, penetratin (pene) and tat, derived from… CONTINUE READING

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