Cytotoxic versus immunoblocking effects of specific alloantibodies: effects of IgM, IgG, and IgG2 on rat kidney allograft survival.

@article{Mullen1977CytotoxicVI,
  title={Cytotoxic versus immunoblocking effects of specific alloantibodies: effects of IgM, IgG, and IgG2 on rat kidney allograft survival.},
  author={Yoko S Mullen and Robert L. Raison and William H. Hildemann},
  journal={Transplantation},
  year={1977},
  volume={24 2},
  pages={99-105}
}
Passively introduced IgM alloantibodies of antidonor specificity regularly led to decreased kidney allograft survival times, whereas IgG alloantibodies from the same hyperimmune sera had a specific immunoblocking effect that promoted prolonged allograft survival. These strikingly opposite effects as a function of antibody isotype occurred across both strong H-1 (Ag-B) and moderate non-H-1 histocompatibility barriers. However, IgM and IgG directed against non-H-1 specificities were far more… CONTINUE READING

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