Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.
@article{Cao2007CytotoxicTS, title={Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.}, author={Shugeng Cao and A. Norris and J. S. Miller and F. Ratovoson and J. Razafitsalama and Rabodo Andriantsiferana and V. Rasamison and Karen Tendyke and T. Suh and D. Kingston}, journal={Journal of natural products}, year={2007}, volume={70 3}, pages={ 361-6 } }
Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Albizia gummifera led to the isolation of three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C (1-3). The structures of these new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1-3 showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.
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