Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.

  title={Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.},
  author={Shugeng Cao and A. Norris and J. S. Miller and F. Ratovoson and J. Razafitsalama and Rabodo Andriantsiferana and V. Rasamison and Karen Tendyke and T. Suh and D. Kingston},
  journal={Journal of natural products},
  volume={70 3},
  • Shugeng Cao, A. Norris, +7 authors D. Kingston
  • Published 2007
  • Biology, Medicine
  • Journal of natural products
  • Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Albizia gummifera led to the isolation of three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C (1-3). The structures of these new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1-3 showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively. 
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