Cytotoxic therapy for severe avian influenza A (H5N1) infection.

  title={Cytotoxic therapy for severe avian influenza A (H5N1) infection.},
  author={J I Henter and Chun Bong Chow and Chi-wai Leung and Yu-Lung Lau},
  volume={367 9513},
The mortality rate in documented avian influenza A virus subtype H5N1 infection is still high, which is currently reported by WHO at about 50%. Post-mortem analyses in affected patients have revealed haemophagocytosis similar to that found in patients with haemophagocytic lymphohistiocytosis (HLH); such haemophagocytosis could be a very prominent post-mortem feature in H5N1 infection. There are also clinical similarities between H5N1 infection and HLH, such as massive hypercytokinaemia… CONTINUE READING


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